Fracture healing in rat femora as affected by functional weight-bearing

J Bone Joint Surg Am. 1977 Apr;59(3):369-75.


Femoral fractures were created in rats to determine whether there were differences in healing under conditions of immobilization and under conditions of immediate weight-bearing. Histological and roentgenographic differences were present by the second week after fracture and differences in mechanical properties were also present. These differences became progressively greater during the next three weeks. Functional weight-bearing was found to accelerate the rate of fracture healing and to improve significantly the strength of the healing bone.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Bony Callus / pathology
  • Early Ambulation
  • Femoral Fractures / physiopathology*
  • Femoral Fractures / surgery
  • Femur / pathology
  • Femur / physiopathology
  • Fracture Fixation
  • Male
  • Rats
  • Rats, Inbred Strains
  • Stress, Mechanical
  • Wound Healing*