Abstract
The caries-preventive efficacy of sweeteners and sugar substitutes is not clearly established on an epidemiological scale. A review of cariogenicity assessments in vitro and in vivo as well as of human clinical caries trials, however, clearly demonstrates that the replacement of sugar by such products has a caries-preventive effect. The clinical relevance of some bacteriostatic and/or cariostatic properties ascribed to saccharin, aspartame, and xylitol remains to be corroborated.
MeSH terms
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Aspartame / therapeutic use
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Cariostatic Agents
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Cyclamates / therapeutic use
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Dental Caries / prevention & control*
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Disaccharides / therapeutic use
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Humans
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Maltose / analogs & derivatives
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Maltose / therapeutic use
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Mannitol / therapeutic use
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Saccharin / therapeutic use
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Sorbitol / therapeutic use
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Sugar Alcohols / therapeutic use
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Sweetening Agents / therapeutic use*
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Xylitol / therapeutic use*
Substances
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Cariostatic Agents
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Cyclamates
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Disaccharides
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Sugar Alcohols
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Sweetening Agents
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Mannitol
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Sorbitol
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Palatinit
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Maltose
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Lycasin
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maltitol
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Saccharin
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lactitol
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Xylitol
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Aspartame