Oxygen radicals induce pulmonary vasoconstriction in pigs without activating plasma proteolytic cascade systems

Eur Surg Res. May-Jun 1993;25(3):137-45. doi: 10.1159/000129268.

Abstract

The effects of infusion of the oxygen radical generating system, hypoxanthine-xanthine oxidase, on pulmonary hemodynamics and plasma proteolytic systems, as the plasma kallikrein-kinin and fibrinolytic systems, were studied in pigs by infusion of xanthine oxidase into the pulmonary circulation. A marked pulmonary vasoconstriction and increase in vasculature resistance with a maximum after 25 min was observed. The effects were attenuated by indomethacin, allopurinol and catalase. During the 130-min observation time there were no signs indicating activation of either the plasma kallikrein or the plasma fibrinolytic systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allopurinol / pharmacology
  • Animals
  • Catalase / pharmacology
  • Female
  • Fibrinolysis / physiology
  • Free Radicals
  • Hypoxanthine
  • Hypoxanthines / pharmacology
  • Indomethacin / pharmacology
  • Kallikrein-Kinin System / physiology
  • Male
  • Pulmonary Circulation / drug effects
  • Pulmonary Circulation / physiology*
  • Reactive Oxygen Species / metabolism*
  • Swine
  • Vascular Resistance / drug effects
  • Vascular Resistance / physiology
  • Vasoconstriction / drug effects
  • Vasoconstriction / physiology*
  • Xanthine Oxidase / pharmacology

Substances

  • Free Radicals
  • Hypoxanthines
  • Reactive Oxygen Species
  • Hypoxanthine
  • Allopurinol
  • Catalase
  • Xanthine Oxidase
  • Indomethacin