The effect of treatment with recombinant human erythropoietin on the histological appearance and glycogen content of skeletal muscle in patients with chronic renal failure treated by regular hospital haemodialysis

Nephron. 1993;64(1):89-94. doi: 10.1159/000187284.

Abstract

The effect of treatment with recombinant human erythropoietin on the histological appearance and glycogen content of the anterior tibialis muscle was studied in 10 patients with chronic renal failure treated by regular haemodialysis. Repeat muscle biopsies taken when the target haemoglobin concentration of 11 g/dl was achieved showed an increase in median glycogen content from 35 mg/g fat-free dry muscle to 51 mg/g (p < 0.05). The histological appearance showed a marked improvement in muscle fibre diameters, in particular for the type I fibres and a reduction in cytoarchitectural abnormalities. These changes would be expected to produce an increase in both muscle strength and performance and are most probably a consequence of an increase in muscle oxygen delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Body Water / metabolism
  • Combined Modality Therapy
  • Erythropoietin / therapeutic use*
  • Female
  • Glycogen / metabolism
  • Humans
  • Kidney Failure, Chronic / metabolism
  • Kidney Failure, Chronic / pathology
  • Kidney Failure, Chronic / therapy*
  • Male
  • Middle Aged
  • Muscles / drug effects*
  • Muscles / metabolism
  • Muscles / pathology
  • Oxygen Consumption / drug effects
  • Potassium / metabolism
  • Renal Dialysis
  • Sodium / metabolism

Substances

  • Erythropoietin
  • Glycogen
  • Sodium
  • Potassium