A majority of proliferating T cells in cutaneous malignant T cell lymphomas may lack the high affinity IL-2 receptor (CD25)

Arch Dermatol Res. 1993;285(3):127-30. doi: 10.1007/BF01112913.


IL-2 is a major growth factor for all T-cell subsets acting via a specific membrane receptor. To investigate its role in the pathogenesis of cutaneous T-cell lymphomas (CTCLs), we analysed the expression of high-affinity IL-2 receptors (IL-2Rs) on proliferating cells in these disorders. We showed by immunohistochemical double staining that most cycling cells do not express high-affinity IL-2Rs. Four T-cell lines were established from patients with CTCLs. Two lines required both IL-2 and IL-4 for growth, one line required IL-2 and one line IL-4 alone. The last of these lacked expression of the IL-2R alpha-chain. Thus, IL-2 may not be the only, or the most important, growth stimulus in CTCLs and reactive skin infiltrates. T helper cells, which dominated the infiltrate, might represent TH2 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / chemistry
  • Cell Division / immunology
  • Humans
  • Ki-67 Antigen
  • Lymphoma, T-Cell, Cutaneous / immunology*
  • Lymphoma, T-Cell, Cutaneous / pathology
  • Neoplasm Proteins / analysis
  • Nuclear Proteins / analysis
  • Receptors, Interleukin-2 / analysis*
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*


  • Biomarkers
  • Ki-67 Antigen
  • Neoplasm Proteins
  • Nuclear Proteins
  • Receptors, Interleukin-2