Dried-blood spot screening for cystic fibrosis in the newborn

Lancet. 1979 Mar 3;1(8114):472-4. doi: 10.1016/s0140-6736(79)90825-0.


Serum-immunoreactive-trypsin (I.R.T.) was measured in children with cystic fibrosis (C.F.) and a variety of controls. In the first few months of life all C.F. children had a raised serum-I.R.T. A dried blood-spot assay for I.R.T. was established and has potential as a screening test for C.F. in the newborn.

MeSH terms

  • Antigens
  • Blood Specimen Collection
  • Blood Stains*
  • Cystic Fibrosis / diagnosis*
  • Cystic Fibrosis / enzymology
  • Humans
  • Infant
  • Infant, Newborn
  • Radioimmunoassay
  • Trypsin / blood*
  • Trypsin / immunology


  • Antigens
  • Trypsin