Infections due to penicillin-resistant pneumococci. Clinical, epidemiologic, and microbiologic features

Arch Intern Med. 1993 Jun 14;153(11):1301-10.


Pneumococcal infection remains a common cause of serious morbidity and mortality throughout the world. Until recently, clinical isolates of pneumococci that were penicillin resistant were rare. However, 4% to 5% of the clinical isolates in the United States were recently found to be either intermediately resistant or highly resistant to penicillin. Clinicians in every field of medicine must therefore be better informed regarding penicillin-resistant pneumococcal infections to minimize their attendant morbidity and mortality and increase compliance with preventive measures. We reviewed the molecular, genetic, and epidemiologic aspects of penicillin-resistant pneumococcal infections, with emphasis on their microbiologic and clinical features.

Publication types

  • Review

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Child
  • Child, Preschool
  • Genes, Bacterial
  • Humans
  • Penicillin Resistance* / genetics
  • Pneumococcal Infections* / drug therapy
  • Pneumococcal Infections* / epidemiology
  • Pneumococcal Infections* / microbiology
  • Pneumococcal Infections* / pathology
  • Streptococcus pneumoniae / genetics
  • Streptococcus pneumoniae / physiology