Apoptosis and signal transduction: clues to a molecular mechanism

Curr Opin Cell Biol. 1993 Apr;5(2):286-91. doi: 10.1016/0955-0674(93)90118-a.


Apoptosis, or programmed cell death, plays an essential role in specific cell deletion during normal embryonic and adult development in vertebrate and invertebrate species. Recent evidence suggests that signal transduction pathways governing cellular proliferation and cell cycle progression also mediate the physiological response to changes in the extracellular environment that trigger the anti-proliferative state characteristic of apoptosis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Calcium / metabolism
  • Protein Kinases
  • Proto-Oncogenes
  • Signal Transduction*
  • Transcription Factors


  • Transcription Factors
  • Protein Kinases
  • Calcium