Normal and abnormal patterns of myelin development of the fetal and infantile human brain using magnetic resonance imaging

Curr Opin Neurol Neurosurg. 1993 Jun;6(3):393-7.


Magnetic resonance imaging allows a noninvasive assessment of myelination during normal brain maturation as well as the detection of genetically determined and acquired diseases that affect the synthesis and maintenance of myelin. If this high sensitivity of magnetic resonance imaging for white matter changes is completed by adequate clinical and biochemical information, a unique diagnostic tool is available to gain new insights in the formation of myelin and pathogenesis of myelin disorders.

Publication types

  • Review

MeSH terms

  • Brain / embryology
  • Brain / pathology
  • Brain Damage, Chronic / diagnosis*
  • Brain Damage, Chronic / embryology
  • Brain Diseases, Metabolic / diagnosis
  • Brain Diseases, Metabolic / embryology
  • Demyelinating Diseases / diagnosis*
  • Demyelinating Diseases / embryology
  • Female
  • Gestational Age
  • Humans
  • Infant
  • Infant, Newborn
  • Magnetic Resonance Imaging*
  • Myelin Sheath / pathology*
  • Pregnancy
  • Risk Factors