Effects of estrogen-progestin replacement therapy on plasma beta-endorphin levels in menopausal women

Biochem Mol Biol Int. 1993 Apr;29(5):831-6.


Serum beta-endorphin, LH, FSH, estradiol (E2) and progesterone (P) were measured in postmenopausal women before and after four different estrogen-progestin replacement therapies. Our result showed that serum E2 increased significantly and serum LH and FSH decreased significantly after all treatments. Serum P levels were similar before and after all treatments. Serum beta-endorphin levels increased significantly after cyclic administration of estrogen-progestin, but not after continuous administration of E2. We conclude that the frequently observed beneficial effects of estrogen-progestin replacement therapy on behavior and mood in postmenopausal women may be related to changes in peripheral opioid levels.

MeSH terms

  • Estrogen Replacement Therapy*
  • Female
  • Follicle Stimulating Hormone / blood
  • Humans
  • Luteinizing Hormone / blood
  • Menopause*
  • Middle Aged
  • Progesterone / blood
  • Progesterone Congeners / therapeutic use*
  • beta-Endorphin / blood*


  • Progesterone Congeners
  • Progesterone
  • beta-Endorphin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone