Male antifertility compounds from Tripterygium wilfordii Hook f

Contraception. 1993 Apr;47(4):387-400. doi: 10.1016/0010-7824(93)90036-7.

Abstract

Extracts of the Chinese medicinal plant, Tripterygium wilfordii, cause reversible infertility in male animals. Sub-fractionation studies have now revealed that the plant extracts contain a number of compounds which are potent antifertility agents in male mammals, including the diterpenes triptolide and tripdiolide and an isomer of the latter. A triptolide, 12,13-chlorohydrin, which is a transformation product formed reversibly by interaction of triptolide with HCl, was also found to be active.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Assay
  • Chromatography, High Pressure Liquid
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology*
  • Epoxy Compounds
  • Fertility / drug effects*
  • Magnetic Resonance Spectroscopy
  • Male
  • Molecular Structure
  • Organ Size / drug effects
  • Phenanthrenes*
  • Rats
  • Serial Extraction
  • Sperm Count / drug effects
  • Sperm Motility / drug effects
  • Spermatocidal Agents / chemistry
  • Spermatocidal Agents / isolation & purification
  • Spermatocidal Agents / pharmacology
  • Tablets
  • Testis / anatomy & histology
  • Testis / drug effects
  • Weight Gain / drug effects

Substances

  • Diterpenes
  • Drugs, Chinese Herbal
  • Epoxy Compounds
  • Phenanthrenes
  • Spermatocidal Agents
  • Tablets
  • tripchlorolide
  • triptolide
  • tripdiolide