Clinical relevance of antibodies to Ro/SS-A and La/SS-B in subacute cutaneous lupus erythematosus and related conditions

Immunol Invest. 1993 Apr;22(3):189-203. doi: 10.3109/08820139309063402.

Abstract

Ro/SS-A autoantibodies are frequently associated with subacute cutaneous lupus erythematosus, neonatal lupus erythematosus and Sjögren's syndrome. The Ro/SS-A autoantigen is a ribonucleoprotein complex consisting of at least four protein components and four small cytoplasmic RNA components designated hY RNA 1, 3, 4 and 5. Three of the Ro/SS-A peptides have been isolated and cloned. The function of this ribonucleoprotein complex is as yet unknown.

Publication types

  • Review

MeSH terms

  • Autoantibodies / genetics
  • Autoantibodies / immunology*
  • Autoantigens / genetics
  • Autoantigens / immunology*
  • Autoimmune Diseases / immunology*
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / immunology*
  • Calreticulin
  • HLA-DR Antigens / genetics
  • HLA-DR Antigens / immunology
  • Heart Block / congenital
  • Heart Block / immunology
  • Humans
  • Immunity, Maternally-Acquired
  • Infant, Newborn
  • Lupus Erythematosus, Cutaneous / immunology*
  • Lupus Erythematosus, Systemic / congenital
  • Lupus Erythematosus, Systemic / immunology
  • RNA, Small Cytoplasmic*
  • Ribonucleoproteins / genetics
  • Ribonucleoproteins / immunology*
  • Sjogren's Syndrome / immunology

Substances

  • Autoantibodies
  • Autoantigens
  • Calcium-Binding Proteins
  • Calreticulin
  • HLA-DR Antigens
  • RNA, Small Cytoplasmic
  • RO60 protein, human
  • Ribonucleoproteins
  • SS-A antigen
  • SS-B antigen