Immunoblastic B-cell malignant lymphoma involving the orbit and maxillary sinus in a patient with acquired immune deficiency syndrome

Ophthalmology. 1993 Jun;100(6):966-70. doi: 10.1016/s0161-6420(93)31547-2.


Background: A 44-year-old man was diagnosed with acquired immune deficiency syndrome (AIDS)-related complex in 1986. Four years later, erythema and swelling of the right lower eyelid and face and a palpable mass along the right inferior orbital rim developed. Computed tomographic scans of the orbits disclosed a mass involving the right superior antrum and inferior orbit. Histopathologic examination and immunohistochemical studies of the tumor were performed.

Methods: Immunohistochemical studies were performed on paraffin sections of the neoplasm. Markers used included leukocyte-common antigen and L26 (pan B-cell marker), and MT1, Leu22, polyclonal CD3, UCHL-1, and OPD4 (pan T-cell markers). Additional markers included cytokeratin, HMB-45, lysozyme, S-100 protein, kappa, and lambda.

Findings: The neoplastic cells were strongly to moderately positive with LCA, L26, MT1, and Leu22. Negative staining was observed with the remaining nine antibodies.

Conclusion: Orbital lymphomas in patients with AIDS have been rarely documented; those few reported cases showed a B-cell phenotype. The authors report an immunoblastic B cell with immunophenotypic coexpression of T-cell markers.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers, Tumor / metabolism
  • Humans
  • Immunoenzyme Techniques
  • Lymphoma, AIDS-Related / metabolism
  • Lymphoma, AIDS-Related / pathology*
  • Male
  • Maxillary Sinus Neoplasms / metabolism
  • Maxillary Sinus Neoplasms / pathology*
  • Orbital Neoplasms / metabolism
  • Orbital Neoplasms / pathology*
  • Tomography, X-Ray Computed


  • Biomarkers, Tumor