Multisection proton MR spectroscopic imaging of the brain

Radiology. 1993 Jul;188(1):277-82. doi: 10.1148/radiology.188.1.8511313.


The authors developed a hydrogen-1 proton magnetic resonance (MR) imaging method in which metabolic information is acquired by obtaining multiple sections through the brain. A spin-echo sequence is used for section selection, an octangular outer volume saturation pulse for lipid suppression, and a chemical-shift-selective saturation pulse for water suppression. High-quality maps of choline, creatine, and N-acetylaspartate were obtained in six studies performed in four volunteers. Water and lipid signal from the skull area was well suppressed by the pulse sequence used.

MeSH terms

  • Adult
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Brain / metabolism*
  • Choline / metabolism
  • Creatine / metabolism
  • Female
  • Humans
  • Lipids
  • Magnetic Resonance Spectroscopy* / methods
  • Male
  • Water


  • Lipids
  • Water
  • Aspartic Acid
  • N-acetylaspartate
  • Creatine
  • Choline