A study of wound healing in the E11.5 mouse embryo by light and electron microscopy

Tissue Cell. 1993;25(2):173-81. doi: 10.1016/0040-8166(93)90017-f.


In this paper we report our light and electron microscopic studies of the healing of a simple excisional lesion to the E11.5 mouse embryo hindlimb. The wounded living embryo is cultured in a roller bottle and under such conditions the lesion is completely re-covered with epithelium by 24 hr. We discuss how our studies of such a simple wound healing model may offer insight into the mechanisms of tissue repair generally.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Death / physiology
  • Culture Techniques
  • Epidermis / embryology
  • Hindlimb / embryology*
  • Mice
  • Microscopy
  • Microscopy, Electron
  • Microscopy, Electron, Scanning
  • Wound Healing / physiology*