Pharmacologic induction of posterior vitreous detachment in the rabbit

Arch Ophthalmol. 1993 Jun;111(6):849-54. doi: 10.1001/archopht.1993.01090060139038.


Objective: To assay the proteolytic activity of plasmin on the vitreoretinal junction and to assess a potential facilitating effect on posterior vitreous detachment.

Methods: We injected 1 U of plasmin into the vitreous of rabbits. Some eyes underwent vitrectomy after plasmin injection. Electroretinography and electron microscopy were performed.

Results: In plasmin-treated eyes, electroretinography displayed a transient (3 days) decreased b-wave amplitude. Histologic examination demonstrated posterior vitreous detachment in eyes that received intravitreal plasmin followed by vitrectomy.

Conclusion: Plasmin may prove to be a useful biochemical adjunct to mechanical vitrectomy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Basement Membrane / drug effects
  • Basement Membrane / ultrastructure
  • Electroretinography
  • Fibrinolysin / pharmacology*
  • Fundus Oculi
  • Microscopy, Electron, Scanning
  • Ophthalmoscopy
  • Rabbits
  • Random Allocation
  • Retina / pathology
  • Vitrectomy / methods*
  • Vitreous Body / drug effects*
  • Vitreous Body / surgery
  • Vitreous Body / ultrastructure


  • Fibrinolysin