Symptomatic sulfadiazine crystalluria in AIDS patients: a report of two cases

Clin Nephrol. 1993 May;39(5):254-6.


As the incidence of toxoplasma encephalitis (TE) in AIDS patients increases, sulfadiazine/pyrimethamine combination therapy is broadly administered. Two cases of acute and chronic renal sulfadiazine crystallization with acute renal failure and nephrolithiasis are reported. Controlled alkalinization of the urine and high fluid intake are recommended for prophylaxis of crystalluria.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy*
  • Acute Kidney Injury / chemically induced*
  • Adult
  • Drug Therapy, Combination
  • Humans
  • Kidney Calculi / chemically induced*
  • Male
  • Pyrimethamine / therapeutic use
  • Sulfadiazine / adverse effects*
  • Sulfadiazine / therapeutic use
  • Toxoplasmosis, Cerebral / drug therapy*


  • Sulfadiazine
  • Pyrimethamine