Expression of MMP-7(PUMP-1) mRNA in human colorectal cancers

Int J Cancer. 1993 Jun 19;54(4):614-8. doi: 10.1002/ijc.2910540415.


The expression of MMP-7 (pump-1) gene was examined in 10 cases of colorectal cancer by utilizing RT-PCR. In 9 out of 10 cases, MMP-7 mRNA was detected in cancerous tissue, whereas none was detected in adjacent normal colon tissue. However, this message was detected in only 1 out of 6 colon-cancer cell lines. In colonic mucosa from 3 patients with ulcerative colitis it was not detected. The expression of MMP-2 (72-kDa type-IV collagenase) mRNA was also investigated in the same tissue samples, and was detected in all samples, including cancerous and non-cancerous tissue. Our data suggest that MMP-7 is expressed in a tumor-associated manner in colorectal cancers and may play a role in tumor progression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Base Sequence
  • Colon / chemistry
  • Colorectal Neoplasms / chemistry*
  • Female
  • Gene Expression
  • Humans
  • Male
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 7
  • Metalloendopeptidases / analysis*
  • Metalloendopeptidases / genetics
  • Middle Aged
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger / analysis*
  • Transcription, Genetic
  • Tumor Cells, Cultured


  • RNA, Messenger
  • Metalloendopeptidases
  • Matrix Metalloproteinase 7
  • Matrix Metalloproteinase 2