Penetration of ciprofloxacin into pleural fluid

J Chemother. 1993 Apr;5(2):110-2. doi: 10.1080/1120009x.1993.11739217.


The penetration of oral 1000 mg/day ciprofloxacin into pleural fluid is investigated in 15 patients with exudative pleural effusion. After 4 days of ciprofloxacin therapy ciprofloxacin concentrations were measured in plasma and pleural exudate simultaneously by high-performance liquid chromatography (HPLC). Mean serum ciprofloxacin level was 1.58 +/- 0.91 mg/L and mean pleural exudate concentration was 1.00 +/- 0.59 mg/L. The concentrations achieved were all above the MIC90 of the majority of Gram-positive and Gram-negative pathogens. It is concluded that ciprofloxacin penetrates well into the pleural fluid.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Ciprofloxacin / pharmacokinetics*
  • Ciprofloxacin / therapeutic use
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pleural Effusion / drug therapy
  • Pleural Effusion / metabolism*


  • Ciprofloxacin