The 6-ketoprostaglandin F1alpha pathway in the lamb ductus arteriousus

Biochim Biophys Acta. 1977 Mar 25;486(3):583-5. doi: 10.1016/0005-2760(77)90113-8.


Homogenates of the lamb ductus arteriosus at term have the capacity to convert exogenous arachidonic acid into prostaglandins E2, F2alpha and 6-ketoprostaglandin F1alpha. No evidence was obtained for the formation of prostaglandin D2 and thromboxane B2. All products were quantitated by mass spectrometry. 6-Ketoprostaglandin F1alpha was the major compound, formed in amounts in excess of 10 fold over prostalgandins E2 and F2alpha.

MeSH terms

  • Animals
  • Arachidonic Acids / metabolism
  • Ductus Arteriosus / metabolism*
  • Female
  • Fetus / metabolism
  • Pregnancy
  • Prostaglandins / biosynthesis
  • Prostaglandins E / biosynthesis
  • Prostaglandins F / biosynthesis*
  • Sheep


  • Arachidonic Acids
  • Prostaglandins
  • Prostaglandins E
  • Prostaglandins F