Secretoneurin releases dopamine from rat striatal slices: a biological effect of a peptide derived from secretogranin II (chromogranin C)

Neuroscience. 1993 May;54(1):1-4. doi: 10.1016/0306-4522(93)90377-r.


Proteolytic processing of secretogranin II (chromogranin C) in brain leads to the formation of a 33-amino acid peptide which we have named secretoneurin. All the properties of secretoneurin are consistent with the concept that this peptide represents a neuropeptide. However, a biological function has not yet been demonstrated. Therefore, we have now investigated whether secretoneurin could alter transmitter release in brain. Slices of rat caudate-putamen were superfused in an in vitro system and dopamine was measured in the superfusate. Secretoneurin dose-dependently increased the outflow of dopamine. This response was abolished in Ca(2+)-free medium. The secretoneurin-response could also be blocked by preincubation of the peptide with a specific antiserum and was subject to rapid specific and reversible desensitization. This effect on dopamine release constitutes the first discovered biological effect found for a peptide derived from secretogranin II. Thus, secretoneurin can be added to the ever-growing number of neuropeptides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caudate Nucleus / metabolism
  • Chromogranins / metabolism*
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism*
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • In Vitro Techniques
  • Neuropeptides / biosynthesis
  • Neuropeptides / pharmacology*
  • Perfusion
  • Proteins*
  • Putamen / metabolism
  • Rats
  • Secretogranin II


  • Chromogranins
  • Neuropeptides
  • Proteins
  • Secretogranin II
  • secretoneurin
  • Dopamine