Unusual charge configurations in transcription factors of the basic RNA polymerase II initiation complex

Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5593-7. doi: 10.1073/pnas.90.12.5593.

Abstract

A systematic analysis of the primary sequences of the polymerase II initiation complex has revealed unusual charge features in the TFII family proteins. In particular, the proteins TFIIA alpha, TFIIE alpha, and TFIIF carry multiple charge clusters and hyper charge runs, sequence features occurring in < 4% of all (available) eukaryotic proteins. Possible implications for these charge structures are discussed in relation to the assembly and function of the polymerase II transcriptional complex.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Conserved Sequence
  • Humans
  • Macromolecular Substances
  • Mice
  • Molecular Sequence Data
  • Protein Conformation
  • RNA Polymerase II / chemistry
  • RNA Polymerase II / metabolism*
  • Rats
  • Saccharomyces cerevisiae / metabolism*
  • Sequence Homology, Amino Acid
  • Transcription Factor TFIIA
  • Transcription Factors / chemistry
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism*
  • Transcription Factors, TFII*

Substances

  • Macromolecular Substances
  • Transcription Factor TFIIA
  • Transcription Factors
  • Transcription Factors, TFII
  • transcription factor TFIIE
  • RNA Polymerase II
  • transcription factor TFIIF