Transcriptional Regulation of Multigene Loci: Multilevel Control

Trends Genet. 1993 Apr;9(4):134-7. doi: 10.1016/0168-9525(93)90208-y.


Recent studies indicate that different levels of control operate within multigene loci. In addition to regulatory sequences immediately flanking the genes, there are also elements that act over long distances on more than one gene. Competition for these elements among genes can influence both the level and timing of gene expression during development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Genes, Regulator / physiology
  • Humans
  • Mice
  • Multigene Family*
  • Regulatory Sequences, Nucleic Acid*
  • Transcription, Genetic*