Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens

Anticancer Res. Mar-Apr 1993;13(2):283-6.


We report here the first orthotopic transplant model for human ovarian cancer. Histologically-intact patient specimens of ovarian cancer were transplanted by microsurgical techniques under the capsule of the nude mouse ovary. The human tumors grew locally and gave rise to a patient-like metastatic pattern including the parietal peritoneum, colon, omentum, and ascites. The orthotopic model described here should be useful for evaluating new therapeutics and diagnostics for ovarian cancer.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Colonic Neoplasms / secondary
  • Disease Models, Animal*
  • Female
  • Humans
  • Mice
  • Mice, Nude
  • Mice, SCID
  • Neoplasm Metastasis / pathology*
  • Neoplasm Transplantation
  • Omentum
  • Ovarian Neoplasms / pathology*
  • Peritoneal Neoplasms / secondary
  • Transplantation, Heterologous*