The interactive role of mucosal T lymphocytes in intestinal growth, development and enteropathy

J Gastroenterol Hepatol. May-Jun 1993;8(3):270-8. doi: 10.1111/j.1440-1746.1993.tb01199.x.

Abstract

Over the past 15-20 years, research has progressively focused on the mucosal T cell as the central factor in the initiation of physiological or pathological changes, first in the growth and maturation of the early (postnatal) intestine, and second in adult-type enteropathies resulting from sensitivity to either food or pathogen-derived antigens. T cell-mediated events may be measured, for example, in terms of specific immunopathologic patterns of change and injury, such as type 1 (lymphocyte infiltration), type 2 (crypt hyperplasia) and type 3 (flat-destructive), which can be recognized and quantitated microscopically; by determination of lymphocyte reactivity through secretion of interleukin-2 receptors (IL-2R) into plasma or expression by mucosal lymphocytes; by quantitation of lymphocyte subsets emigrating into inflamed tissues by immunoperoxidase-labelled monoclonal antibodies; or by the determination of T cell receptor polymorphisms. Alterations in intestinal growth, structure and function at weaning are likely to be T cell-mediated as they are analogous to the same type 1/2 lesions that reflect modulation of adult mucosal architecture in food and parasite-induced hypersensitivity reactions. Enteropathies associated with HIV infection and T cell deficiency display a milder degree of villous flattening and impaired crypt hyperplasia than that typical of gluten-sensitivity, suggesting a reversion to lesser degrees of mucosal pathology (type 1/2). Clearly more information will accrue; meanwhile the remarks in this brief survey should provide a firm basis whereby clinician and scientist can meet, and together recognize and further dissect the modulatory effect of T lymphocytes on mucosal structure and function.

Publication types

  • Review

MeSH terms

  • Animals
  • Graft vs Host Reaction / physiology
  • Humans
  • Intestinal Diseases / pathology
  • Intestinal Diseases / physiopathology*
  • Intestinal Mucosa / embryology
  • Intestinal Mucosa / growth & development
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / pathology
  • T-Lymphocytes / physiology*