Abl tyrosine protein kinase

Semin Immunol. 1995 Aug;7(4):255-66. doi: 10.1006/smim.1995.0030.


Mammalian c-Abl belongs to an evolutionary conserved family of non-receptor tyrosine kinases. It is distributed both in the cytoplasm in association with F-actin, and in the nucleus where it binds chromatin. The normal function of c-Abl is poorly understood. Nevertheless, there has been rapid progress in the characterization of the structural features, signal transduction pathways, substrates and ligands involved in the action of c-Abl and Abl-derived oncogenes. These developments suggest that several mechanisms co-operate to allow regulation of normal cell growth by c-Abl and induction of leukemias by Bcr-abl.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Molecular Sequence Data
  • Protein-Tyrosine Kinases*
  • Proto-Oncogene Proteins c-abl*


  • Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins c-abl

Associated data

  • GENBANK/U29420
  • GENBANK/X02596