The response to treatment of overweight in postmenopausal women is not related to fat distribution

Int J Obes Relat Metab Disord. 1995 Jul;19(7):496-502.


Objective: To investigate whether fat distribution or sex hormone status in overweight postmenopausal women do influence the response to treatment of overweight.

Design: Longitudinal, clinical intervention study of a 4.2 MJ diet daily with or without exercise.

Subjects: 98 healthy, overweight, postmenopausal women (age: 49-58 y, BMI: 25-42 kg/m2).

Measurements: Various fatness and fat distribution parameters (by dual-energy x-ray absorptiometry and anthropometry), sex hormone-binding globulin (SHBG), sex hormones, and the resting energy expenditure (REE) at baseline and after 3 months.

Results: Reductions in weight and fat were independent of the initial fat distribution and the REE, but were significantly associated with high initial SHBG levels. Furthermore, loss of fat was significantly and independently associated with increases in SHBG and reductions in central fat distribution.

Conclusion: Postmenopausal women with an android and gynoid fat distribution respond with similar weight loss to treatment of overweight. Furthermore, a more healthy, less android, fat distribution and sex hormone status may be achieved with increasing weight loss.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Androstenedione / blood
  • Anthropometry
  • Body Composition / physiology*
  • Diet, Reducing / standards
  • Energy Metabolism / physiology
  • Estradiol / blood
  • Exercise / physiology
  • Female
  • Gonadal Steroid Hormones / blood*
  • Humans
  • Longitudinal Studies
  • Middle Aged
  • Obesity / metabolism
  • Obesity / physiopathology*
  • Obesity / therapy*
  • Postmenopause / physiology*
  • Sex Hormone-Binding Globulin / analysis
  • Testosterone / blood


  • Gonadal Steroid Hormones
  • Sex Hormone-Binding Globulin
  • Testosterone
  • Androstenedione
  • Estradiol