Pseudomonas aeruginosa, mucoidy and the chronic infection phenotype in cystic fibrosis

Trends Microbiol. 1995 Sep;3(9):351-6. doi: 10.1016/s0966-842x(00)88974-x.


During chronic infections in cystic fibrosis, persistence of Pseudomonas aeruginosa is associated with conversion into forms that are associated with conversion into forms that are characterized by a mucoid colony morphology, rough lipopolysaccharide and, paradoxically, decreased systemic virulence. The mutations underlying these changes occur in global regulators, such as alternative sigma factors and their accessory elements.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacterial Capsules / biosynthesis*
  • Base Sequence
  • Chronic Disease
  • Cystic Fibrosis / complications*
  • Genes, Bacterial / physiology*
  • Humans
  • Lung Diseases / complications
  • Lung Diseases / microbiology*
  • Molecular Sequence Data
  • Mutation / genetics*
  • Phenotype
  • Pseudomonas Infections / complications
  • Pseudomonas Infections / microbiology*
  • Pseudomonas aeruginosa / pathogenicity
  • Pseudomonas aeruginosa / physiology*
  • Transformation, Bacterial / genetics

Associated data

  • GENBANK/L41667
  • GENBANK/U15180