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, 83 (6), 835-9

The Nuclear Receptor Superfamily: The Second Decade


The Nuclear Receptor Superfamily: The Second Decade

D J Mangelsdorf et al. Cell.


Figure 1.
Figure 1.
Structures of the Known Ligands for Nuclear Hormone Receptors
Figure 2.
Figure 2.. Nuclear Receptors Share Common Structure/Function Domains
A typical nuclear receptor contains a variable N-terminal region (A/B), a conserved DBD (C), a variable hinge region (D), a conserved LBD (E), and a variable C-terminal region (F). Nuclear receptors can be grouped into four classes according to their ligand binding, DNA binding, and dimerization properties: steroid receptors, RXR heterodimers, homodimeric orphan receptors, and monomeric orphan receptors. Shown are representative receptors for each group. A complete listing is given in Figure 3. Question marks refer to orphan receptors for which ligands are not known. See accompanying reviews for details.
Figure 3.
Figure 3.
Known Members of the Nuclear Receptor Superfamily

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