Malaria therapy and prophylaxis with cotrifazid, a multiple complex combination consisting of rifampicin + isoniazid + sulfamethoxazole + trimethoprim

Chemotherapy. 1995 Sep-Oct;41(5):396-8. doi: 10.1159/000239372.

Abstract

This report contains the first therapeutic results with the multiple combination rifampicin + isoniazid + sulfamethoxazole + trimethoprim in the treatment of malaria. Clinical symptoms declined rapidly and parasites were cleared from the erythrocytes. Tolerance was excellent. This fixed combination is outstandingly practicable, with few problems with compliance.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Drug Combinations
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Isoniazid / therapeutic use*
  • Malaria / drug therapy*
  • Male
  • Middle Aged
  • Rifampin / therapeutic use*
  • Sulfamethoxazole / therapeutic use*
  • Trimethoprim / therapeutic use*

Substances

  • Drug Combinations
  • cotrifazid
  • Trimethoprim
  • Sulfamethoxazole
  • Isoniazid
  • Rifampin