Differential characteristics and localisation of [3H]oxazoline and [3H]imidazoline binding sites in rat kidney

Eur J Pharmacol. 1995 Aug 15;281(3):341-6. doi: 10.1016/0014-2999(95)00335-i.


Comparative autoradiography revealed that the imidazolines [3H]p-aminoclonidine and [3H]idazoxan labelled high densities of alpha 2A-adrenoceptor sites in the inner medulla and inner stripe of the outer medulla of rat kidney. In contrast, the oxazoline [3H]rilmenidine labelled a high density of non-adrenergic sites in the cortex and outer stripe of the outer medulla, a lower density in the inner stripe and inner medulla and a low density of alpha 2A-adrenoceptor sites in inner medulla. The existence of novel, non-adrenergic oxazoline sites of potential functional importance in rat kidney has important implications for the classification of imidazoline receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic alpha-Antagonists / pharmacology*
  • Animals
  • Autoradiography
  • Binding Sites
  • Dioxanes / pharmacology*
  • Idazoxan
  • Imidazoles / pharmacology*
  • Kidney / drug effects*
  • Male
  • Oxazoles / pharmacology*
  • Radioligand Assay
  • Rats
  • Rats, Inbred WKY
  • Rilmenidine


  • Adrenergic alpha-Antagonists
  • Dioxanes
  • Imidazoles
  • Oxazoles
  • Rilmenidine
  • Idazoxan