Circumvention of multidrug resistance in neoplastic cells through scavenger receptor mediated drug delivery

FEBS Lett. 1995 Nov 27;376(1-2):95-8. doi: 10.1016/0014-5793(95)01250-6.

Abstract

A conjugate of the antineoplastic drug daunomycin (DNM) with maleylated bovine serum albumin (MBSA-DNM) was taken up with high efficiency by a multidrug resistant variant, JD100, of the murine-macrophage tumour cell line, J774A.1, through the scavenger receptors resulting in cessation of DNA synthesis. In contrast, free DNM at similar concentrations did not affect the incorporation of [3H]thymidine by these cells. These results suggest that receptor-mediated intracellular delivery of antineoplastic drugs could be a viable and new approach for overcoming the problem of multidrug resistance in chemotherapy of neoplastic diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / administration & dosage*
  • Antibiotics, Antineoplastic / metabolism
  • Antibiotics, Antineoplastic / pharmacology
  • Cell Survival / drug effects
  • Daunorubicin / administration & dosage*
  • Daunorubicin / metabolism
  • Daunorubicin / pharmacology
  • Drug Delivery Systems*
  • Drug Resistance, Multiple*
  • Endocytosis
  • Macrophages / metabolism
  • Maleates / pharmacology
  • Mice
  • Poly G / pharmacology
  • Receptors, Drug / metabolism*
  • Serum Albumin, Bovine / metabolism
  • Tumor Cells, Cultured
  • Verapamil / pharmacology

Substances

  • Antibiotics, Antineoplastic
  • Maleates
  • Receptors, Drug
  • Poly G
  • Serum Albumin, Bovine
  • Verapamil
  • Daunorubicin