Inheritance of migraine investigated by complex segregation analysis

Hum Genet. 1995 Dec;96(6):726-30. doi: 10.1007/BF00210307.


Migraine is the most common neurological disorder, affecting about 20% of adults. The mode of inheritance was analyzed in the two main types of migraine, migraine without aura (MO) and migraine with aura (MA), by complex segregation analysis using the computer program POINTER. We included 126 probands with MO and 127 probands with MA from the general population. First-degree relatives and spouses were blindly interviewed by a neurological research fellow. The complex segregation analysis indicated that both MO and MA have multifactorial inheritance without generational difference.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Child
  • Crosses, Genetic
  • Factor Analysis, Statistical
  • Female
  • Gene Frequency
  • Genes, Dominant
  • Homozygote
  • Humans
  • Male
  • Migraine Disorders / epidemiology
  • Migraine Disorders / genetics*
  • Migraine Disorders / physiopathology
  • Models, Genetic*
  • Prevalence
  • Sex Characteristics
  • Software