Functional connectivity in the motor cortex of resting human brain using echo-planar MRI

Magn Reson Med. 1995 Oct;34(4):537-41. doi: 10.1002/mrm.1910340409.


An MRI time course of 512 echo-planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the sensorimotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI). Time courses of low frequency (< 0.1 Hz) fluctuations in resting brain were observed to have a high degree of temporal correlation (P < 10(-3)) within these regions and also with time courses in several other regions that can be associated with motor function. It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acoustic Stimulation
  • Adult
  • Brain / metabolism
  • Brain / physiology*
  • Cerebrovascular Circulation
  • Echo-Planar Imaging*
  • Electroencephalography
  • Female
  • Fingers / physiology
  • Hand / physiology
  • Humans
  • Magnetic Resonance Imaging* / methods
  • Male
  • Motor Cortex / metabolism
  • Motor Cortex / physiology*
  • Motor Skills
  • Movement
  • Neurons / physiology
  • Oxygen / blood
  • Photic Stimulation
  • Psychomotor Performance
  • Rest*
  • Somatosensory Cortex / metabolism
  • Somatosensory Cortex / physiology


  • Oxygen