Stress Signaling in Yeast

Bioessays. 1995 Nov;17(11):959-65. doi: 10.1002/bies.950171109.

Abstract

In the yeast Saccharomyces cerevisiae three positive transcriptional control elements are activated by stress conditions: heat shock elements (HSEs), stress response elements (STREs) and AP-1 responsive elements (AREs). HSEs bind heat shock transcription factor (HSF), which is activated by stress conditions causing accumulation of abnormal proteins. STREs mediate transcriptional activation by multiple stress conditions. They are controlled by high osmolarity via the HOG signal pathway, which comprises a MAP kinase module and a two-component system homologous to prokaryotic signal transducers. AREs bind the transcription factor Yap1p. The three types of control elements seem to have overlapping, but distinct functions. Some stress proteins encoded by HSE-regulated genes are necessary for growth of yeast under moderate stress, products of STRE-activated genes appear to be important for survival under severe stress and ARE-controlled genes may mainly function during oxidative stress and in the response to toxic conditions, such as caused by heavy metal ions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Genes, Fungal
  • Heat-Shock Proteins / genetics
  • Heat-Shock Proteins / physiology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology*
  • Signal Transduction / genetics
  • Signal Transduction / physiology
  • Transcription Factor AP-1 / genetics

Substances

  • Heat-Shock Proteins
  • Transcription Factor AP-1
  • Cyclic AMP-Dependent Protein Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases