Degradation of high molecular weight poly(L-lactide) in alkaline medium

Biomaterials. 1995 Jul;16(11):833-43. doi: 10.1016/0142-9612(95)94144-a.

Abstract

To study the effect of molecular weight and morphology on hydrolytic degradation, four poly(L-lactide)s (PLLAs) with average molecular weight of 3.0 x 10(5), 4.5 x 10(5), 6.5 x 10(5) and 3 x 10(6) were used. PLLA films with different morphologies were obtained by solution casting. Degradation of the films was performed at 37 degrees C in 0.01 N NaOH solution and this alkaline hydrolysis seemed to simulate well the real case while offering significant acceleration of the degradation process. Diverse microscopy techniques (light, polarizing and scanning electron) were used to study the surface change of morphology and erosion of the PLLA films. Swelling was visualized by scanning electron microscopy, particularly on the spherulites, which were eroded from the centre by hydrolysis. In the case of highly amorphous film, crystallization took place as degradation proceeded. The reduction in transparency of PLLA films, measured by a spectrophotometer at 570 nm, was ascribed to the increased density of spherulites. Differential scanning calorimetry revealed that the crystallinity of PLLA increased with degradation time, in accordance with accelerated spherulite formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials
  • Biodegradation, Environmental
  • Calorimetry, Differential Scanning
  • Crystallization
  • Delayed-Action Preparations / metabolism*
  • Hydrogen-Ion Concentration
  • In Vitro Techniques
  • Lactates / chemistry
  • Lactates / metabolism*
  • Lactic Acid*
  • Microscopy, Electron, Scanning
  • Molecular Weight
  • Particle Size
  • Polyesters
  • Polymers / chemistry
  • Polymers / metabolism*
  • Sodium Hydroxide / chemistry*
  • Spectrophotometry, Ultraviolet
  • Surface Properties
  • Temperature
  • Thermodynamics

Substances

  • Biocompatible Materials
  • Delayed-Action Preparations
  • Lactates
  • Polyesters
  • Polymers
  • Lactic Acid
  • poly(lactide)
  • Sodium Hydroxide