Cytokine concentrations in sputum of asthmatic patients

Int Arch Allergy Immunol. 1996 Jan;109(1):73-8. doi: 10.1159/000237234.


To examine whether levels of inflammatory cytokines and eosinophil cationic protein (ECP) in the sputum reflect the severity of bronchial asthma, we measured their levels in the sputum of symptomatic and asymptomatic asthmatics. Interleukin (IL)-1 beta, IL-5, IL-6, IL-8, RANTES, tumor necrosis factor-alpha and ECP concentrations in the sputum of symptomatic patients were significantly higher than in asymptomatic subjects. These findings suggest that these inflammatory cytokines are involved in the exacerbation of asthma.

MeSH terms

  • Adult
  • Asthma / complications*
  • Blood Proteins / analysis
  • Chemokine CCL5 / analysis
  • Cytokines / analysis*
  • Enzyme-Linked Immunosorbent Assay
  • Eosinophil Granule Proteins
  • Female
  • Humans
  • Inflammation Mediators / analysis
  • Male
  • Middle Aged
  • Ribonucleases*
  • Sputum / immunology*


  • Blood Proteins
  • Chemokine CCL5
  • Cytokines
  • Eosinophil Granule Proteins
  • Inflammation Mediators
  • Ribonucleases