Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat

Nat Genet. 1996 Jan;12(1):31-7. doi: 10.1038/ng0196-31.


Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Body Weight
  • Chromosome Mapping
  • DNA Primers / chemistry
  • Diabetes Mellitus, Type 2 / genetics*
  • Disease Models, Animal
  • Fasting
  • Female
  • Genetic Linkage
  • Glucose / metabolism
  • Hyperglycemia / genetics
  • Insulin / genetics
  • Male
  • Molecular Sequence Data
  • Rats
  • Rats, Inbred F344
  • Rats, Mutant Strains / genetics*


  • DNA Primers
  • Insulin
  • Glucose