Electroporation theory. Concepts and mechanisms

Methods Mol Biol. 1995:55:3-28. doi: 10.1385/0-89603-328-7:3.

Abstract

The basic features of electrical and mechanical behavior of electroporated cell membranes are reasonably well established experimentally. Overall, the electrical and mechanical features of electroporation are consistent with a transient aqueous pore hypothesis, and several features, such as membrane rupture and reversible electrical breakdown, are reasonably well described quantitatively. This gives confidence that "electroporation" is an attractive hypothesis, and that the appearance of temporary pores owing to the simultaneous contributions of thermal fluctuations ("kT energy") and an elevated transmembrane voltage ("electric field energy") is the microscopic basis of electroporation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Membrane / physiology*
  • Electroporation* / methods
  • Humans
  • Kinetics
  • Lipid Bilayers
  • Mathematics
  • Membrane Lipids / physiology
  • Membrane Potentials
  • Models, Theoretical
  • Thermodynamics

Substances

  • Lipid Bilayers
  • Membrane Lipids