Native-like and structurally characterized designed alpha-helical bundles

Curr Opin Struct Biol. 1995 Aug;5(4):457-63. doi: 10.1016/0959-440x(95)80029-8.


A number of coiled coils and alpha-helical bundles have recently been designed, and many have now been structurally characterized by X-ray crystallography. Others have not been as well characterized structurally but exhibit native-like properties in aqueous solution. Both areas of investigation have contributed greatly to our understanding of the nature of specificity in this class of molecules.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Crystallography, X-Ray
  • Molecular Sequence Data
  • Protein Conformation
  • Protein Structure, Secondary*
  • Solutions


  • Solutions