Structures of bacterial immunoglobulin-binding domains and their complexes with immunoglobulins

Curr Opin Struct Biol. 1995 Aug;5(4):471-81. doi: 10.1016/0959-440x(95)80031-x.


Three-dimensional structures are now available for several immunoglobulin binding domains from bacterial proteins A, G, and L. X-ray diffraction and NMR experiments on complexes of these domains with portions of immunoglobulins have revealed common structural themes used in these interactions. These data expand our understanding of structure/function relationships in these molecular recognition processes and provide the basis for rational design of artificial immunoglobulin-binding molecules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / chemistry*
  • Binding Sites, Antibody
  • Immunoglobulin Fragments / chemistry
  • Molecular Sequence Data
  • Staphylococcal Protein A / chemistry


  • Bacterial Proteins
  • Ig L-binding protein, Peptostreptococcus
  • IgG Fc-binding protein, Streptococcus
  • Immunoglobulin Fragments
  • Staphylococcal Protein A