Bending membranes to the task: structural intermediates in bilayer fusion

Curr Opin Struct Biol. 1995 Aug;5(4):541-7. doi: 10.1016/0959-440x(95)80041-7.


Merger of lipid bilayers plays a central role in diverse biological fusion reactions. Recent studies suggest that different membrane fusion systems, including fusion of purely lipid bilayers, involve formation of similar stalk-type intermediates--highly bent (net negative curvature) and transient lipidic connections between fusing membranes.

Publication types

  • Review

MeSH terms

  • Cell Membrane / chemistry
  • Cell Membrane / physiology
  • Lipid Bilayers / chemistry*
  • Membrane Fusion*


  • Lipid Bilayers