Cloning and sequence analysis of the Corynebacterium diphtheriae dtxR homologue from Streptomyces lividans and S. pilosus encoding a putative iron repressor protein

Gene. 1995 Dec 1;166(1):117-9. doi: 10.1016/0378-1119(95)00628-7.


The iron-regulated promoter involved in desferrioxamine B synthesis of Streptomyces pilosus contains a region homologous to the iron repressor (DtxR)-binding site of the diphtheria toxin gene promoter in Corynebacterium diphtheriae [Günter et al., J. Bacteriol. 175 (1993) 3295-3302]. Here, we report the cloning and sequencing of the putative Streptomyces iron repressor gene, homologous to dtxR of C. diphtheriae. The N-terminal 139 amino acids of the deduced protein are 73% identical to DtxR.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / genetics
  • Base Sequence
  • Cloning, Molecular
  • Corynebacterium diphtheriae / genetics
  • DNA, Bacterial / genetics
  • DNA-Binding Proteins / genetics
  • Genes, Bacterial
  • Iron / metabolism*
  • Molecular Sequence Data
  • Repressor Proteins / genetics*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Streptomyces / genetics*


  • Bacterial Proteins
  • DNA, Bacterial
  • DNA-Binding Proteins
  • DtxR protein, Corynebacterium diphtheriae
  • Repressor Proteins
  • Iron

Associated data

  • GENBANK/Z50048
  • GENBANK/Z50049