Effect of biguanide treatment in obese children

Helv Paediatr Acta. 1977 Apr;31(6):473-80.


In seven children of normal weight and in nine obese children (more than 30% overweight) from 8 to 14 years of age, blood glucose and insulin levels were estimated. The obese children were then treated with dimethylbiguanide (Metformin-HCl) during 3 months. After this period the tests were repeated. It is shown that a significant reduction of the insulin values, insulinogen indices and weight occurred after this treatment.

MeSH terms

  • Adolescent
  • Blood Glucose / analysis
  • Child
  • Fasting
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood*
  • Metformin / therapeutic use*
  • Obesity / drug therapy*


  • Blood Glucose
  • Insulin
  • Metformin