Abstract
A 2.1-kb cDNA probe encoding the human SH2-domain containing protein-tyrosine phosphatase SH-PTP2 (PTPN11) was hybridized to human metaphase chromosomes in three independent experiments. In each instance, hybridization was maximal to chromosome 12q24.1-q24.3. The presence of SH-PTP2 cDNA crosshybridizing sequences located on a number of other chromosomes suggested that SH-PTP2-related genes or pseudogenes are present in the human genome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromosome Mapping
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Chromosomes, Human, Pair 12 / genetics*
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DNA Probes
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Humans
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In Situ Hybridization
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Intracellular Signaling Peptides and Proteins
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Protein Tyrosine Phosphatase, Non-Receptor Type 11
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Protein Tyrosine Phosphatase, Non-Receptor Type 6
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Protein Tyrosine Phosphatases / genetics*
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SH2 Domain-Containing Protein Tyrosine Phosphatases
Substances
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DNA Probes
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Intracellular Signaling Peptides and Proteins
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PTPN11 protein, human
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PTPN6 protein, human
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Protein Tyrosine Phosphatase, Non-Receptor Type 11
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Protein Tyrosine Phosphatase, Non-Receptor Type 6
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Protein Tyrosine Phosphatases
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SH2 Domain-Containing Protein Tyrosine Phosphatases