Differentially regulated expression of human IgG Fc receptor class III genes

Immunobiology. 1995 Jul;193(2-4):341-55. doi: 10.1016/s0171-2985(11)80564-4.

Abstract

The expression of the human Fc receptor with low affinity for IgG (Fc gamma RIII, CD16) encoded by the Fc gamma RIII-A or Fc gamma RIII-B genes is restricted to natural killer (NK), a subset of T cells and macrophages or neutrophils (PMN). The genetic heterogeneity of Fc gamma RIII generates alternative membrane-anchored proteins with distinct signaling capacities when cross-linked by immune complexes. Of great importance is the characterization of the regulatory gene elements directing the expression of a particular Fc gamma RIII isoform to a given specific cell type. Molecular characterization of the Fc gamma RIII-A and Fc gamma RIII-B genes has revealed that the promoter regions display distinct tissue-specific transcriptional activities. In addition, the differential Fc gamma RIII-A/B gene activation can be regulated by enhancer elements located in the more upstream and intron regions. Transcription initiation in NK cells occurs also outside the normal promoter region by a second independent Fc gamma RIII-A promoter. Analysis of the additional Fc gamma RIIIa2-4 transcripts suggests the expression of novel, as yet unknown Fc gamma RIII receptor isoforms on NK cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Deoxyribonuclease I
  • Enhancer Elements, Genetic / immunology
  • Gene Expression Regulation / immunology*
  • Humans
  • Introns / immunology
  • Killer Cells, Natural / metabolism
  • Molecular Sequence Data
  • Promoter Regions, Genetic / immunology
  • Receptors, IgG / biosynthesis*
  • Receptors, IgG / chemistry
  • Receptors, IgG / genetics*
  • Transcription, Genetic / immunology
  • Transcriptional Activation

Substances

  • Receptors, IgG
  • Deoxyribonuclease I