Review
doi: 10.1016/s0968-0004(00)89086-6.
The base excision repair pathway
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- PMID: 8533150
- DOI: 10.1016/s0968-0004(00)89086-6
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Review
The base excision repair pathway
Trends Biochem Sci.
1995 Oct.
Abstract
The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating agents, which are similar to those induced by endogenous factors.
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