Review
doi: 10.1016/s0968-0004(00)89087-8.
Mismatch repair: mechanisms and relationship to cancer susceptibility
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- PMID: 8533151
- DOI: 10.1016/s0968-0004(00)89087-8
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Review
Mismatch repair: mechanisms and relationship to cancer susceptibility
Trends Biochem Sci.
1995 Oct.
Abstract
DNA mismatch-repair systems exist that repair mispaired bases formed during DNA replication, genetic recombination and as a result of damage to DNA. Some components of these systems are conserved in prokaryotes and eukaryotes. Genetic defects in mismatch-repair genes play an important role in common cancer-susceptibility syndromes and sporadic cancers.
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