DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK

Trends Biochem Sci. 1995 Oct;20(10):412-5. doi: 10.1016/s0968-0004(00)89090-8.


Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA
  • DNA Damage / radiation effects
  • DNA Repair*
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins*
  • Gene Rearrangement*
  • Genetic Complementation Test
  • Mammals / genetics
  • Models, Genetic
  • Mutation
  • Protein-Serine-Threonine Kinases / genetics*
  • Recombination, Genetic*


  • DNA-Binding Proteins
  • DNA
  • DNA-Activated Protein Kinase
  • Protein-Serine-Threonine Kinases