Cisplatin and DNA repair in cancer chemotherapy

Trends Biochem Sci. 1995 Oct;20(10):435-9. doi: 10.1016/s0968-0004(00)89095-7.


Cisplatin, a DNA-damaging agent, is one of the most widely used anticancer drugs. As with all members of this class of chemotherapeutic compounds, the clinical success of cisplatin is compromised if tumor cells become resistant by various mechanisms, including enhanced DNA repair. In addition to its role in resistance, DNA repair has been linked to the cytotoxic mechanism of cisplatin. DNA damaged by the drug has proved to be a valuable tool for exploring the details of the nucleotide excision repair pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Line
  • Cisplatin / therapeutic use*
  • DNA Adducts
  • DNA Damage
  • DNA Repair*
  • Drug Resistance, Neoplasm
  • High Mobility Group Proteins / genetics
  • Humans
  • Leukemia / drug therapy
  • Leukemia / genetics
  • Leukemia / pathology
  • Mice
  • Models, Genetic
  • Neoplasms / drug therapy*
  • Neoplasms / genetics


  • DNA Adducts
  • High Mobility Group Proteins
  • Cisplatin